Regioselective Suzuki–Miyaura Cross-Coupling Reactions of the Bis(triflate) of 1,4-Dihydroxy-9H-fluoren-9-one

1,4-Diaryl-9H-fluoren-9-ones were prepared by regioselective Suzuki–Miyaura cross-coupling reaction of the bis(triflate) of 1,4-dihydroxy-9H-fluoren-9-one. The reactions proceeded with excellent site selectivity. The first attack occurs at position 1, due to electronic reason

Semiclassical Solution of the Quantum Hydrodynamic Equation for Trapped Bose-condensed Gas in the l=0 Case

In this paper the quantum hydrodynamic equation describing the collective, low energy excitations of a dilute atomic Bose gas in a given trapping potential is investigated with the JWKB semiclassical method. In the case of spherically symmetric harmonic confining potential a good agreement is shown between the semiclassical and the exact energy eigenvalues as well as wave functions. It is also demonstrated that for larger quantum numbers the calculation of the semiclassical wave function is numerically more stable than the exact polynomial with large alternating coefficients.Comment: 12 pages, 7 figure

First Measurement of the 96^{96}Ru(p,γ\gamma)97^{97}Rh Cross Section for the p-Process with a Storage Ring

This work presents a direct measurement of the $^{96}$Ru($p, \gamma$)$^{97}$Rh cross section via a novel technique using a storage ring, which opens opportunities for reaction measurements on unstable nuclei. A proof-of-principle experiment was performed at the storage ring ESR at GSI in Darmstadt, where circulating $^{96}$Ru ions interacted repeatedly with a hydrogen target. The $^{96}$Ru($p, \gamma$)$^{97}$Rh cross section between 9 and 11 MeV has been determined using two independent normalization methods. As key ingredients in Hauser-Feshbach calculations, the $\gamma$-ray strength function as well as the level density model can be pinned down with the measured ($p, \gamma$) cross section. Furthermore, the proton optical potential can be optimized after the uncertainties from the $\gamma$-ray strength function and the level density have been removed. As a result, a constrained $^{96}$Ru($p, \gamma$)$^{97}$Rh reaction rate over a wide temperature range is recommended for $p$-process network calculations.Comment: 10 pages, 7 figs, Accepted for publication at PR

Measuring gratitude in Germany: Validation study of the German versions of the Gratitude Questionnaire-Six Item Form (GQ-6-G) and the Multi-Component Gratitude Measure (MCGM-G)

The Gratitude Questionnaire-Six Item Form (GQ-6; McCullough et al., 2002) is a well-established instrument for measuring gratitude. Recently, the Multi-Component Gratitude Measure (MCGM) was developed as a more holistic approach (Morgan et al., 2017). While the GQ-6 mainly focuses on the emotional component of gratitude, the MCGM encompasses conceptual, attitudinal, and behavioral aspects. As of today, there is no validated German measure for gratitude. In order to close that research gap, the present study focused on validating the German versions of the GQ-6 (GQ-6-G) and of the MCGM (MCGM-G). In addition, multi-group comparisons were conducted to test for cultural measurement invariance. Construct validity was tested similar to original validation studies of the two scales focusing on affect, well-being, empathy, anxiety and depression. The online survey was completed in random order by 508 participants. The one-factor model of the GQ-6-G and the hierarchical structure of the MCGM-G could be replicated. However, the model fit of the Gratitude Questionnaire was significantly better after eliminating one item (GQ-5-G). Multi-group comparisons revealed cultural measurement invariance was established for the GQ-5-G and partial measurement invariance for five of six factors of the MCGM-G, respectively. Reliability analyses revealed good internal consistency for both instruments, and measures for criterion-related and discriminant validity have shown hypothesized relationships. Thus, the GQ-5-G and the MCGM-G are two instruments with good reliability and validity for measuring gratitude in Germany

A Facile Strategy for In Situ Core-Template-Functionalizing Siliceous Hollow Nanospheres for Guest Species Entrapment

The shell wall-functionalized siliceous hollow nanospheres (SHNs) with functional molecules represent an important class of nanocarriers for a rich range of potential applications. Herein, a self-templated approach has been developed for the synthesis of in situ functionalized SHNs, in which the biocompatible long-chain polycarboxylates (i.e., polyacrylate, polyaspartate, gelatin) provide the framework for silica precursor deposition by simply controlling chain conformation with divalent metal ions (i.e., Ca2+, Sr2+), without the intervention of any external templates. Metal ions play crucial roles in the formation of organic vesicle templates by modulating the long chains of polymers and preventing them from separation by washing process. We also show that, by in situ functionalizing the shell wall of SHNs, it is capable of entrapping nearly an eightfold quantity of vitamin Bc in comparison to the bare bulk silica nanospheres. These results confirm the feasibility of guest species entrapment in the functionalized shell wall, and SHNs are effective carriers of guest (bio-)molecules potentially for a variety of biomedical applications. By rationally choosing the functional (self-templating) molecules, this concept may represent a general strategy for the production of functionalized silica hollow structures

Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications

This work was supported by a restricted research grant of Bayer AG